MAP3K14 antibody (N-Term)

Catalog No. ABIN2775274

The Rabbit Polyclonal anti-MAP3K14 antibody has been validated for WB. It is suitable to detect MAP3K14 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit and Guinea Pig.

Quick Overview for MAP3K14 antibody (N-Term) (ABIN2775274)

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAP3K14 Antibody

Binding Specificity: N-Term

Sequence: SEAGPAAISI IAQAECENSQ EFSPTFSERI FIAGSKQYSQ SESLDQIPNN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MAP3K14. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K14

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 947 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Alternative Name: MAP3K14

Background: This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Alias Symbols: FTDCR1B, HS, HSNIK, NIK
Protein Interaction Partner: UBC, TRAF3, TRAF2, BIRC2, TRAF1, IKBKB, HSP90AA1, CHUK, TRAF6, TNAP, PELI3, TRAF5, TANK, NFKB2, ARRB2, ZFP91, EEF1A1, PEBP1, HSP90AB1, CDC37, MAP3K14, EDAR, IKBKAP, RPL6, RPL5, RIPK1, MAP3K7, MAPK3, CASP8, GRB14, GRB10, GRB7, MAP2K4, IKBKG, MAP3K8, RPL4,
Protein Size: 947

Molecular Weight: 104 kDa

Gene ID: 9020

NCBI Accession: NM_003954, NP_003945

UniProt: Q99558

Pathways: NF-kappaB Signaling, TCR Signaling